Amongst the dead was a 7-year-old boy and a person, found as a result of a storm in Holly Springs, Mississippi, according to the mayor. No further details about the circumstances were immediately available. At least 15 people were injured there. Search and rescue efforts will continue overnight, Mayor Kelvin Buck told ABC News.
Also killed were a husband and wife, both in their 60s and another 6--year old man, according to Benton County Sheriff's Department.
Dramatic photos of the storm bearing down on Holly Springs emerged Wednesday night.
At least six counties reported damage in Mississippi, where at least 40 were reported injured, and search and rescues were being conducted there.
One of the storms, a reported tornado, hit Bellevue, Mississippi, damaging 10-15 homes, at least 7 of which were destroyed, according to the Coahoma County Emergency Management.
Five injuries were reported there and 2 additional severe injuries were reported near Shannon Airport, in the Clarksdale, MS area, the department said.
In nearby Como, MS, at least two homes were damaged.
In Perry County, Tennessee, there are two confirmed fatalities.
In Wayne County, Tennessee, there was major structural damage to several buildings and homes in the area, but it was unclear how many, according to Wayne County Sheriff Ric Wilson. There were several injuries as well, he said.
In Atkins, Arkansas, police, fire and rescue officials were dispatched to a residence on an entrapment call. High winds and heavy rain had caused a large tree to uproot and fall onto a house. An 18-year-old woman and an 18-month toddler were inside. The toddler was extricated by emergency personnel and transported to an area hospital. The woman was pronounced dead at the scene.
Some 68 million Americans were forecast to be in the path of the storms Wednesday night.
A "particularly dangerous situation" tornado watch was issued from Monroe, Louisiana, to Jackson, Tennessee, meaning there was a good chance of long-track tornadoes.
In addition to Mississippi, severe storms were predicted for parts of Kentucky, Tennessee, Alabama, Indiana, Illinois, Missouri, Arkansas and Alabama.